@article{APM11983,
author = {Stephanie Chan and Liying Zhang and Leigha Rowbottom and Rachel McDonald and Georg A. Bjarnason and May Tsao and Elizabeth Barnes and Cyril Danjoux and Marko Popovic and Henry Lam and Carlo DeAngelis and Edward Chow},
title = {Effects of circadian rhythms and treatment times on the response of radiotherapy for painful bone metastases},
journal = {Annals of Palliative Medicine},
volume = {6},
number = {1},
year = {2016},
keywords = {},
abstract = {Background: Previous studies have observed how the time of radiotherapy delivery can impact toxicities and outcomes. The goal of this study was to determine whether treatment time influenced radiotherapy response for bone metastases.
Methods: Patients who received radiation treatment to painful bone metastases from January 2000 to December 2010 were included in our analysis. Demographic and treatment information including performance status, primary site, treatment dose and fraction, and response were collected prospectively. Treatment times were extracted from patient medical records. Patients were allocated to 8:00 AM–11:00 AM, 11:01 AM–2:00 PM, or 2:01 PM–5:00 PM cohorts based on their treatment times. To compare treatment response between the three cohorts, the Fisher exact test was used. A two-sided P value of },
issn = {2224-5839}, url = {https://apm.amegroups.org/article/view/11983}
}