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Epigallocatechin gallate reduces uric acid levels by regulating xanthine oxidase activity and uric acid excretion in vitro and in vivo

   
@article{APM33495,
	author = {Fang Li and Yaping Liu and Yongyan Xie and Zhiyong Liu and Guoming Zou},
	title = {Epigallocatechin gallate reduces uric acid levels by regulating xanthine oxidase activity and uric acid excretion in vitro and in vivo},
	journal = {Annals of Palliative Medicine},
	volume = {9},
	number = {2},
	year = {2019},
	keywords = {},
	abstract = {Background: This study investigates the effect of epigallocatechin gallate (EGCG) from tea leaves on hyperuricemia and explores the underlying mechanisms in vitro and in vivo.
Methods: The effects of EGCG on proliferation of BRL 3A rat liver cells were evaluated by CCK8 and after stimulation by xanthine the uric acid and xanthine oxidase (XOD) levels were evaluated by a kit; In an in vivo experiment, rats were treated with oxonic acid potassium salt combined with ethylamine pyrimidine to induce high uric acid hematic disease (7 days), The serum uric acid levels and XOD levels were evaluated by a kit, The expressions of OTA1 and GLUT9 were detected by RT-qPCR and Immunohistochemical. 
Results: EGCG had no effect on proliferation, and significantly reduced serum uric acid levels and inhibited XOD activity (P},
	issn = {2224-5839},	url = {https://apm.amegroups.org/article/view/33495}
}