@article{APM34902,
author = {Dong Zhen and Bing Qiu and Weiguo Wang and Zhirong Yang and Jingwei Wang and Yang Gan and Bing Qiu},
title = {Proprioceptive changes measured by histopathological and electrophysiological evaluations after NGF injection of anterior cruciate ligament reconstruction},
journal = {Annals of Palliative Medicine},
volume = {9},
number = {1},
year = {2020},
keywords = {},
abstract = {Background: Proprioceptive recovery has received an increased amount of attention after undergoing anterior cruciate ligament (ACL) reconstruction. However, ACL reconstruction without rehabilitation training could not significantly improve the reduction and function of the proprioceptor. This study aimed to explore whether nerve growth factor (NGF) could cause proprioceptive changes after ACL reconstruction through histopathological and electrophysiological evaluations.
Methods: A total 28 mature New Zealand white rabbits were used in the study, 24 to develop the model of ACL injury and ACL reconstruction. These included the experimental group (n=12; injected with NGF 20 µg/week at the second month after surgery) and the experimental control group (n=12), and 4 for blank control group. In the 4th, 8th, and 12th months, the changes in ACL nerves were measured by somatosensory evoked potentials (SEPs) and electromyogram (EMG). Furthermore, gold chloride staining was performed to detect the changes in morphology and quantity of the proprioceptors in ACL.
Results: Electrophysiological tests showed that the incubation of SEPs and EMG in both the experimental group and the experimental control group were prolonged, and the amplitude decreased when compared with the blank control group (all, P},
issn = {2224-5839}, url = {https://apm.amegroups.org/article/view/34902}
}