Bone metastases are an important cause of mortality and quality of life (QoL) impairment in patients with advanced cancer (1). In addition to lung and liver, the skeleton is one of the most affected site by distant metastasis (2,3). Different skeletal-related events are associated to bone metastasis and known to effectively reduce life expectancy and significantly compromise QoL (4). Pain, pathological fractures, hypercalcemia, bone marrow suppression and neuronal compression are some examples of skeletal-related events, commonly seen in clinical practice.
