Brain metastases in HER2-positive breast cancer: challenges and opportunities

The development of metastases in the central nervous system (CNS) is one of the most devastating consequences of breast cancer progression (1). Although epidemiologic studies estimate that the incidence of brain metastases (BM) in women with metastatic breast cancer (MBC) is 10-16% (2,3), reports from autopsies suggest rates of up to 30% (2,4,5).